Discrete Gradient Flows for Shape Optimization and Applications We present a variational framework for shape optimization problems that hinges on devising energy decreasing flows, based on shape differential calculus, followed by suitable space and time discretizations (discrete gradient flows). A key ingredient is the flexibility in choosing appropriate descent directions by varying the scalar products, used for computation of normal velocity, on the deformable domain boundary. We discuss applications to optimal shape design for PDE, surface diffusion, and image segmentation, along with several simulations exhibiting large deformations as well as pinching and topological changes in finite time. This work is joint with E. Baensch, G. Dogan, P. Morin, and M. Verani. An important resolution issue, critical for large domain deformations and new paradigm in adaptivity, is geometrically consistent mesh refinement of polyhedral surfaces. We discuss recent results joint with A. Bonito and M.S. Pauletti.